Mechanisms and Targets of Deep Brain Stimulation in Movement Disorders
β Scribed by Matthew D. Johnson; Svjetlana Miocinovic; Cameron C. McIntyre; Jerrold L. Vitek
- Publisher
- Springer-Verlag
- Year
- 2008
- Tongue
- English
- Weight
- 292 KB
- Volume
- 5
- Category
- Article
- ISSN
- 1933-7213
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Stimulation of the thalamic nucleus ventralis intermedius (Vim) at high (130-Hz) frequency has been used over the last 8 years as a treatment in 134 patients with movement disorders (91 Parkinson's disease [PD], 23 essential tremor [ET], 21 various dyskinesias and dystonias, including four multiple
High frequency electrical stimulation by means of electrodes implanted into the brain (deep brain stimulation; DBS) recently has become an accepted technique for the treatment of several movement disorders and in particular for Parkinson's disease. Because the effects produced by DBS are similar to
The mechanism of action of high frequency deep brain stimulation is still unknown. However, in all circumstances and in all target nuclei so far stimulated, the effects mimic those of lesions previously made during thalamotomies, pallidotomies or even subthalamotomies, suggesting an inhibition of at