✦ LIBER ✦

Mechanisms of deep brain stimulation

✍ Scribed by Jonathan O. Dostrovsky; Andres M. Lozano

Publisher: John Wiley and Sons
Year: 2002
Tongue: English
Weight: 153 KB
Volume: 17
Category: Article
ISSN: 0885-3185
DOI: 10.1002/mds.10143

No coin nor oath required. For personal study only.

✦ Synopsis

High frequency electrical stimulation by means of electrodes implanted into the brain (deep brain stimulation; DBS) recently has become an accepted technique for the treatment of several movement disorders and in particular for Parkinson's disease. Because the effects produced by DBS are similar to those produced by making a lesion in the same region, it has been proposed that the overall effect of DBS is to inhibit the neural activity in the region stimulated. However, whether this is actually the case is presently not known, but various mechanisms have been proposed in an attempt to explain how DBS could mimic the effects of a lesion. We describe the various mechanisms that have been proposed to account for the inhibition or disruption of the pathologic outflow by high-frequency DBS, ranging from depolarisation block to stimulation-evoked release of gamma-aminobutyric acid and describes preliminary findings that show that stimulation within these structures can result in inhibition.

📜 SIMILAR VOLUMES

Mechanisms of deep brain stimulation

✍ Alim L. Benabid; Abdelhamid Benazzous; Pierre Pollak 📂 Article 📅 2002 🏛 John Wiley and Sons 🌐 English ⚖ 21 KB

The mechanism of action of high frequency deep brain stimulation is still unknown. However, in all circumstances and in all target nuclei so far stimulated, the effects mimic those of lesions previously made during thalamotomies, pallidotomies or even subthalamotomies, suggesting an inhibition of at

Mechanisms of deep brain stimulation: Ex

Mechanisms of deep brain stimulation: Excitation or inhibition

✍ Jerrold L. Vitek 📂 Article 📅 2002 🏛 John Wiley and Sons 🌐 English ⚖ 30 KB

There is little debate that deep brain stimulation (DBS) has been an effective tool in the treatment of Parkinson's disease as well as other movement disorders. There remains however, considerable debate concerning the mechanism(s) underlying its beneficial effect. The comparable effect of stimulati

Latest view on the mechanism of action o

Latest view on the mechanism of action of deep brain stimulation

✍ Constance Hammond; Rachida Ammari; Bernard Bioulac; Liliana Garcia 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 310 KB

## Abstract How does deep brain stimulation (DBS) applied at high frequency (100 Hz and above, HFS) in diverse points of cortico‐basal ganglia thalamo‐cortical loops alleviate symptoms of neurological disorders such as Parkinson's disease, dystonia, and obsessive compulsive disorders? Do the effect

Complications of deep brain stimulation

Complications of deep brain stimulation surgery

✍ Marwan I. Hariz 📂 Article 📅 2002 🏛 John Wiley and Sons 🌐 English ⚖ 34 KB

Currently, DBS is a commonly performed surgery for treatment of movement disorders, especially Parkinson's disease. Although nonablative and minimally invasive, this procedure may give rise to many complications and side effects, some of which are neither reversible nor adaptable. This study reviews

Deep brain stimulation for dystonia

✍ Anthony E. Lang 📂 Article 📅 2011 🏛 John Wiley and Sons 🌐 English ⚖ 47 KB

Deep brain stimulation: Preoperative iss

Deep brain stimulation: Preoperative issues

✍ Anthony E. Lang; Jean-Luc Houeto; Paul Krack; Cynthia Kubu; Kelly E. Lyons; Elen 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 English ⚖ 185 KB