Mechanism of thyroid hormone biosynthesis. Enzymatic oxidative coupling of 3,5-diiodo-l-tyrosine derivatives

✍ Scribed by You-An Ma; Charles J. Sih

• Book ID: 104262433
• Publisher: Elsevier Science
• Year: 1999
• Tongue: French
• Weight: 248 KB
• Volume: 40
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(99)01655-x

✦ Synopsis

Both enzymatic and non-enzymatic oxidative coupling of 3,5-diiodo-L-tyrosine derivatives afforded a T4 derivative and a C3 fragment. The C3 fragment is not dehydroalanine as was claimed by previous workers but rather it was identified as aminomalonic semialdehyde, which decomposed to hydroxypyruvate, 3, in the acidic work-up. The latter was isolated as its osazone derivative, 6.