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Mechanism of the reaction between cis-[PtCl2(NH3)2] and DNA in vitro

โœ Scribed by Johnson, N. P.; Mazard, A. M.; Escalier, J.; Macquet, J. P.


Book ID
111888629
Publisher
American Chemical Society
Year
1985
Tongue
English
Weight
660 KB
Volume
107
Category
Article
ISSN
0002-7863

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โœ Jean-Pierre Macquet; Theophile Theophanides ๐Ÿ“‚ Article ๐Ÿ“… 1975 ๐Ÿ› Elsevier Science โš– 434 KB

In the present study the nature and the hydrolysis of DNA-I% complexes with the platinum compounds, [Pt(dien)C1]Cl, Imns-and ~rlrPt(NH~),Ci,, using potentiometric chloride determinations, have been investigated. The tmns-Pt(NH,),C1, and the [Pt(dien)Cl] Cl react with the GC planes at the N,(G) sites