Mechanism of muscle wasting in myotonic dystrophy
โ Scribed by Robert C. Griggs; Ralph Jozefowicz; William Kingston; K. Sreekumaran Nair; Barbara E. Herr; David Halliday
- Publisher
- John Wiley and Sons
- Year
- 1990
- Tongue
- English
- Weight
- 740 KB
- Volume
- 27
- Category
- Article
- ISSN
- 0364-5134
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
Muscle fiber contractile dysfunction in myotonic dystrophy (MD) is poorly understood. We biopsied the tibialis anterior of two symptomatic and three asymptomatic subjects (aged 21-31 years) with the MD mutation. Biopsies were freeze dried. A total of 103 single muscle fibers were activated with Ca +
In myotonic dystrophy (DM), the expansion of CTG triplet repeats in the 3'-untranslated region of DM-protein kinase (DMPK) is a causal gene mutation. However, the pathogenic molecular mechanism of CTG repeat expansion for DM phenotypic expression is unclear. To investigate this issue, we examined th