✦ LIBER ✦

Mechanism of Mu DNA transposition

✍ Scribed by George Chaconas; Michael G. Surette

Book ID: 102761556
Publisher: John Wiley and Sons
Year: 1988
Tongue: English
Weight: 594 KB
Volume: 9
Category: Article
ISSN: 0265-9247
DOI: 10.1002/bies.950090606

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✦ Synopsis

The study of Mu DNA transposition in vitro has resulted in a much better understanding of the biochemical details of the transposition process. An early step in transposition is the generation of a B structure which is the product of the strand-transfer reaction. The polarity of the strand transfer has been determined and substantial progress has been made on the role of the individual proteins. Moreover, the strand-transfer reaction is mediated by stable protein-DNA complexes, or transpososomes, and the reaction can be divided into two sequential steps. The role of the transpososomes and the requirement for a supercoiled Mu DNA substrate are also discussed.

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