Mechanism of inhibition of insulin-stimulated glucose transport by 4-bromocrotonic acid in 3T3-L1 adipocytes
β Scribed by Shin-Pei Chai; Jim C Fong
- Book ID
- 114283751
- Publisher
- Elsevier Science
- Year
- 2003
- Tongue
- English
- Weight
- 284 KB
- Volume
- 15
- Category
- Article
- ISSN
- 0898-6568
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π SIMILAR VOLUMES
## Abstract We used nigericin, a K^+^/H^+^ exchanger, to test whether glucose transport in 3T3βL1 adipocytes was modulated by changes in intracellular pH. Our results showed that nigericin increased basal but decreased insulinβstimulated glucose uptake in a timeβ and doseβdependent manner. Whereas
It is well established that somatotropin (GH) antagonizes insulin action in vivo and that supraphysiologic concentrations of GH frequently result in insulin resistance and glucose intolerance. However, the demonstration of an anti-insulin activity by GH in vitro has been difficult. This study, there