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Mechanism of cytotoxicity mediated by the C31 fragment of the amyloid precursor protein

✍ Scribed by Sun Ah Park; Gideon M. Shaked; Dale E. Bredesen; Edward H. Koo

Book ID
116299065
Publisher
Elsevier Science
Year
2009
Tongue
English
Weight
507 KB
Volume
388
Category
Article
ISSN
0006-291X

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## Abstract The AICD (APP intracellular Domain) and C31, caspase‐cleaved C‐terminal fragment of APP, have been found in Alzheimer's disease (AD) patients' brains and have been reported to induce apoptosis in neuronal cells. In recent, the C‐terminal fragments of amyloid precursor protein (APP‐CTs)