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Mechanism of constitutive activation of FLT3 with internal tandem duplication in the juxtamembrane domain

✍ Scribed by Kiyoi, Hitoshi; Ohno, Ryuzo; Ueda, Ryuzo; Saito, Hidehiko; Naoe, Tomoki

Book ID: 110066535
Publisher: Nature Publishing Group
Year: 2002
Tongue: English
Weight: 270 KB
Volume: 21
Category: Article
ISSN: 0950-9232
DOI: 10.1038/sj.onc.1205332

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## Background. Recently, an internal tandem duplication of the FLT3 gene (FLT3/ITD) was found in 20% of adult cases of acute myelogenous leukemia (AML), and this length abnormality was suggested to be associated with leukemic progression. Procedure. We examined the mRNA expression of the FLT3 gene