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Mechanism of biosynthesis of squalene from sesquiterpenoids

✍ Scribed by J.W. Cornforth; G. Popják

Publisher
Elsevier Science
Year
1959
Tongue
French
Weight
292 KB
Volume
1
Category
Article
ISSN
0040-4039

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✦ Synopsis

ALTHOUGH farnesyl pyrophosphate (I) has been shown to produce squalene when incubated with yeast cell particles and reduced triphosphopyridine nucleotide, ' the detailed mechanism of this change is still unknown. The two hypotheses previously advanced 192 are incompatible with the new data2 obtained by using hydrogen isotopes to study the biosynthesis of squalene from mevalonic acid.

CH3 -C = CH -CH2 -CH2 -C -CR -CH2 -CH2 -C -CH -CH2 -0P206H3

We now propose an alternative scheme based on the discovery of acid-.

labile derivatives, presumably pyrophosphates, of both nerolidol and farnesol in a liver enzyme system after incubation with mevalonate.3

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