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Mechanism of active transcriptional repression by the retinoblastoma protein

โœ Scribed by Weintraub, Steven J.; Chow, Kevin N. B.; Luo, Robin X.; Zhang, Steven H.; He, Song; Dean, Douglas C.


Book ID
109793375
Publisher
Nature Publishing Group
Year
1995
Tongue
English
Weight
576 KB
Volume
375
Category
Article
ISSN
0028-0836

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Regulation of transcription by the retin
โœ Jonathan M. Horowitz ๐Ÿ“‚ Article ๐Ÿ“… 1993 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 908 KB

The product of the retinoblastoma gene ( R B I ) is believed to function as a negative regulator of cell growth. Recent experimental results suggest that RBI may exert its growth-suppressing activity by regulating the transcription of a variety of growthrelated genes, including FOS, MYC, and TGFB /.