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Mechanism of action on B cell lymphoma by chimeric anti-CD20 monoclonal antibody

โœ Scribed by Oyama, T; Kagami, Y; Seto, M; Morishima, Y


Book ID
110055002
Publisher
Nature Publishing Group
Year
2001
Tongue
English
Weight
68 KB
Volume
15
Category
Article
ISSN
0887-6924

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Rituximab is a chimeric anti CD-20 monoclonal antibody containing human IgG1 kappa constant regions, with murine variable regions. The anti-lymphoma effects of Rituximab are probably due to complement and antibody-dependent cell-mediated cytotoxicity, and induction of apoptosis. Phase II trials have