Monoclonal Antibody Therapy for B-Cell Lymphoma: Clinical Trials of an Anti-CD20 Monoclonal Antibody for B-Cell Lymphoma in Japan
โ Scribed by Kensei Tobinai
- Publisher
- Carden Jennings Publishing
- Year
- 2002
- Tongue
- English
- Weight
- 276 KB
- Volume
- 76
- Category
- Article
- ISSN
- 0925-5710
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
Rituximab is a chimeric anti CD-20 monoclonal antibody containing human IgG1 kappa constant regions, with murine variable regions. The anti-lymphoma effects of Rituximab are probably due to complement and antibody-dependent cell-mediated cytotoxicity, and induction of apoptosis. Phase II trials have
Preliminary clinical trials suggest that iodine-131 ( 131 I)labeled anti-CD20 monoclonal antibodies (MAbs) are effective single agents for the treatment of relapsed non-Hodgkin's B-cell lymphomas. However, despite high initial response rates, most patients treated in this manner will eventually rela