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Mechanism of action of retinyl compounds on wound healing II: Effect of active retinyl derivatives on granuloma formation

โœ Scribed by K. H. Lee; Theodore G. Tong


Publisher
John Wiley and Sons
Year
1970
Tongue
English
Weight
359 KB
Volume
59
Category
Article
ISSN
0022-3549

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โœฆ Synopsis


The naturally occurring retinyl derivatives that promote wound healing as measured by their effects on tensile strength of healing wounds also stimulate granuloma formation induced by cotton pellets. The hexosamine and hydroxyproline contents in the granuloma affected by retinyl derivatives are also increased. The mechanisms of action of retinyl derivation on wound healing are discussed.

Keyphrases 0 Retinyl compounds--effect on granuloma formation 0 Granuloma formation-retinyl derivatives, effects 0 Wound healing-mechanism of action, retinyl derivatives


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Oral administration of sodium salicylate or prednisone and topical application of salicylic acid or hydrocortisone in NIB retards healing and the inhibitory action of either one of these drugs can be reversed by local application of retinoic acid. Topical application of retinol, retinyl esters, or r