Hypothesis: Thalidomide embryopathy?prop
β
Stephens, Trent D.; Fillmore, Bradley J.
π
Article
π
2000
π
John Wiley and Sons
π
English
β 98 KB
π 1 views
We propose that thalidomide affects the following pathway during limb development: Growth factors (FGF-2 and IGF-I) attach to receptors on limb bud mesenchymal cells and initiate some second messenger system (perhaps SP-1), which activates β£v and β€3 integrin subunit genes. The resulting β£v β€3 integr