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Mechanism of action in thalidomide teratogenesis

✍ Scribed by Trent D Stephens; Carolyn J.W Bunde; Bradley J Fillmore


Book ID
113994715
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
413 KB
Volume
59
Category
Article
ISSN
0006-2952

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We propose that thalidomide affects the following pathway during limb development: Growth factors (FGF-2 and IGF-I) attach to receptors on limb bud mesenchymal cells and initiate some second messenger system (perhaps SP-1), which activates ␣v and ␀3 integrin subunit genes. The resulting ␣v ␀3 integr

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