𝔖 Bobbio Scriptorium
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Comments on “Proposed Mechanisms of Action in Thalidomide Embryopathy”

✍ Scribed by Koch, Heinrich P.


Book ID
112219013
Publisher
John Wiley and Sons
Year
1990
Tongue
English
Weight
124 KB
Volume
41
Category
Article
ISSN
0040-3709

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Hypothesis: Thalidomide embryopathy?prop
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We propose that thalidomide affects the following pathway during limb development: Growth factors (FGF-2 and IGF-I) attach to receptors on limb bud mesenchymal cells and initiate some second messenger system (perhaps SP-1), which activates ␣v and ␤3 integrin subunit genes. The resulting ␣v ␤3 integr