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Mechanism for regulation of immune responses

✍ Scribed by Jan Jaroszewski; Aftab Ahmed; Kenneth W. Sell

Publisher
Elsevier Science
Year
1976
Tongue
English
Weight
479 KB
Volume
57
Category
Article
ISSN
0022-5193

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✦ Synopsis

During the course of several lines of investigation carried out in our laboratory, evidence has been accumulating that would suggest a possible mechanism for the regulation of immune responses. We suggest that a new antigen is produced on the surface of lymphocytes following antigenic recognition and induction of blast transformation; and that these new surface "blast" antigens may induce the immune reaction of another lymphocyte. If such new antigens are specific for the original antigenic stimulus, the immune response against the antigen-specific blast cells might provide the way of controlling immune responses. This reaction might also produce the stimulus necessary to stimulate B lymphocytes to produce antibody (T-helper function).

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