Cell death in the regulation of immune responses
β Scribed by Astar Winoto
- Publisher
- Elsevier Science
- Year
- 1997
- Tongue
- English
- Weight
- 568 KB
- Volume
- 9
- Category
- Article
- ISSN
- 0952-7915
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β¦ Synopsis
Cell death is an integral part of the functioning of the immune system. For T cells, potentially autoreactive or 'useless' cells are removed through apoptosis in response to signals (or lack of signals) from their T cell receptor complex. A myriad of proteins that can initiate or protect cells from cell death have recently been identified.
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During the course of several lines of investigation carried out in our laboratory, evidence has been accumulating that would suggest a possible mechanism for the regulation of immune responses. We suggest that a new antigen is produced on the surface of lymphocytes following antigenic recognition an