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Mechanism-Based Inactivation of Human Cytochrome P450 1A2 by Furafylline: Detection of a 1:1 Adduct to Protein and Evidence for the Formation of a Novel Imidazomethide Intermediate †

✍ Scribed by Racha, Jagdish K.; Rettie, Allan E.; Kunze, Kent L.


Book ID
120638202
Publisher
American Chemical Society
Year
1998
Tongue
English
Weight
168 KB
Volume
37
Category
Article
ISSN
0006-2960

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## Abstract The inhibitory effects of flavonoids on the human cytochrome P450 1A2 (CYP1A2) were examined. Among flavonoids tested, galangin, kaempferol, chrysin, and apigenin were potent inhibitors. Although apigenin belonging to flavones and genistein belonging to isoflavones are similar in the ch