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Characterization of the structural determinants required for potent mechanism-based inhibition of human cytochrome P450 1A1 by cannabidiol

โœ Scribed by Yamaori, Satoshi; Okushima, Yoshimi; Yamamoto, Ikuo; Watanabe, Kazuhito


Book ID
122242559
Publisher
Elsevier Science
Year
2014
Tongue
English
Weight
806 KB
Volume
215
Category
Article
ISSN
0009-2797

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Differential mechanisms for the inhibiti
โœ Hideaki Shimada; Masashi Eto; Misa Ohtaguro; Michihiro Ohtsubo; Yosuke Mizukami; ๐Ÿ“‚ Article ๐Ÿ“… 2010 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 240 KB

## Abstract The inhibitory effects of flavonoids on the human cytochrome P450 1A2 (CYP1A2) were examined. Among flavonoids tested, galangin, kaempferol, chrysin, and apigenin were potent inhibitors. Although apigenin belonging to flavones and genistein belonging to isoflavones are similar in the ch