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Mechanism-based combination telomerase inhibition therapy

✍ Scribed by Jerry W. Shay; Woodring E. Wright


Book ID
113523520
Publisher
Elsevier Science
Year
2005
Tongue
English
Weight
136 KB
Volume
7
Category
Article
ISSN
1535-6108

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## Abstract The ends of human chromosomes are protected from the degradation associated with cell division by 15–20 kb long segments of hexameric repeats of 5′‐TTAGGG‐3β€² termed telomeres. In normal cells telomeres lose up to 300 bp of DNA per cell division that ultimately leads to senescence; howev