Stereochemistry and mechanism of the GDP
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Philip J. Oths; Robert M. Mayer; Heinz G. Floss
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Article
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1990
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Elsevier Science
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English
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The reaction catalyzed by bacterial GDP-mannose dehydratase (E.C. 4.2.1.47), the conversion of GDP-D-mannose to GDP-4-keto-6-deoxymannose (GDP-6-deoxy-D-lyxo-hexos-4-ulose), was studied with (6R)- and (6S)-GDP-D-[4-2H1,6-3H]mannose. Conversion of these stereospecifically labeled substrates in the pr