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Mechanical stretch augments insulin-induced vascular smooth muscle cell proliferation by insulin-like growth factor-1 receptor

โœ Scribed by Gang Liu; Hirofumi Hitomi; Naohisa Hosomi; Bai Lei; Daisuke Nakano; Kazushi Deguchi; Hirohito Mori; Tsutomu Masaki; Hong Ma; Kathy K. Griendling; Akira Nishiyama


Book ID
113956133
Publisher
Elsevier Science
Year
2011
Tongue
English
Weight
826 KB
Volume
317
Category
Article
ISSN
0014-4827

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Vascular smooth muscle cells synthesize
โœ Wendie S. Cohick; Amy Gockerman; David R. Clemmons ๐Ÿ“‚ Article ๐Ÿ“… 1993 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 1021 KB

Vascular smooth muscle cells (SMC) synthesize insulin-like growth factor-I (ILF-I), which is a mitogen for this cell type in vitro. Since IGF binding proteins (IGFBP) modulate IGF bioactivity, we determined which IGFBPs were secreted by porcine SMC. Porcine SMC secreted 34,000 and 24,000 M, forms of