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Is insulin-induced growth of vascular smooth muscle cells mediated by the insulin-like growth factor receptor?

โœ Scribed by K. Kamide; M.T. Hori; B. Ormsby; J.D. Barrett; P. Eggena; M.L. Tuck


Book ID
117603895
Publisher
Nature Publishing Group
Year
1998
Tongue
English
Weight
102 KB
Volume
11
Category
Article
ISSN
0895-7061

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Vascular smooth muscle cells synthesize
โœ Wendie S. Cohick; Amy Gockerman; David R. Clemmons ๐Ÿ“‚ Article ๐Ÿ“… 1993 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 1021 KB

Vascular smooth muscle cells (SMC) synthesize insulin-like growth factor-I (ILF-I), which is a mitogen for this cell type in vitro. Since IGF binding proteins (IGFBP) modulate IGF bioactivity, we determined which IGFBPs were secreted by porcine SMC. Porcine SMC secreted 34,000 and 24,000 M, forms of