Mechanical strain in actin networks regulates FilGAP and integrin binding to filamin A
β Scribed by Ehrlicher, A. J.; Nakamura, F.; Hartwig, J. H.; Weitz, D. A.; Stossel, T. P.
- Book ID
- 115541482
- Publisher
- Nature Publishing Group
- Year
- 2011
- Tongue
- English
- Weight
- 874 KB
- Volume
- 478
- Category
- Article
- ISSN
- 0028-0836
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Actinβbinding protein (ABPβ280; filamin) is a phosphoprotein present in the periphery of the cytoplasm, where it can crossβlink actin filaments, associate with lipid membranes, and bind to membrane surface receptors. Given its function and localization in the cell, the hypothesis that it serves as a
Integrins are a family of transmembrane proteins composed of heterodimers of β£ and β€ subunits. With their extracellular domain they bind extracellular matrix proteins or other cell surface molecules, and their cytoplasmic domain binds to cytoskeletal and signaling proteins. Thus, they are in an idea