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Mechanical properties of OI type III bone tissue measured by nanoindentation

✍ Scribed by Zaifeng Fan; Peter A. Smith; Eugene C. Eckstein; Gerald F. Harris

Publisher: John Wiley and Sons
Year: 2006
Tongue: English
Weight: 124 KB
Volume: 79A
Category: Article
ISSN: 1549-3296
DOI: 10.1002/jbm.a.30713

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✦ Synopsis

Abstract

Nanoindentation was used to characterize the intrinsic mechanical properties of bone tissue from eight (8) children with type III Osteogenesis Imperfecta (OI). The bone samples were harvested from the cortex portion at the site of bowing (the mid 2/3 of the shaft of the tibia/femur). Unlike normal bone tissue, OI type III cortical bone exhibited more isotropic material properties. Young's modulus and hardness values measured in the longitudinal direction did not show significant differences from the transverse measurements. No differences were observed in modulus or hardness in an analysis of the cortical and trabecular samples. The deformation patterns of the OI type III bone during nanoindentation were found to be similar to those of normal adult bone in an analysis of the ratio of modulus to hardness. No correlation was found between nanoindentation measurement and age in an analysis of regression. © 2006 Wiley Periodicals, Inc. J Biomed Mater Res, 2006

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