Haloperidol and other dopaminergic (DA) blockers have long been known to induce catalepsy. Recently, it has been reported that nicotine potentiates the cataleptic effect of haloperidol. However, this presents a quandary in terms of neural interactions between nicotinic and DA systems. Nicotine promo
โฆ LIBER โฆ
Mecamylamine Effects on Haloperidol-Induced Catalepsy and Defecation
โ Scribed by Sanberg, Paul R.; Newman, Mary B.; Manresa, John J.; Potts, Sarah E.; Alvarez, Franco; Cahill, David W.; Shytle, R. Douglas
- Book ID
- 111927184
- Publisher
- Informa plc
- Year
- 2001
- Tongue
- English
- Weight
- 544 KB
- Volume
- 109
- Category
- Article
- ISSN
- 0020-7454
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Pretreatment with quipazine, a serotonin agonist, and clomipramine, a selective serotonin neuronal uptake blocker, was found to potentiate the cataleptic effect of haloperidol in a dose-dependent manner in rats. Pretreatment with methysergide, a serotonin antagonist, reduced the cataleptic effect of