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Measuring Conformational Dynamics: A New FCS-FRET Approach

โœ Scribed by Torres, Tedman; Levitus, Marcia


Book ID
127284859
Publisher
American Chemical Society
Year
2007
Tongue
English
Weight
198 KB
Volume
111
Category
Article
ISSN
0022-3654

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We report the combined use of steady-state fluorescence resonance energy transfer (FRET) experiments and molecular dynamics (MD) simulations to investigate conformational distributions of the prion protein (PrP) repeat system. FRET was used for the first time to probe the distance, as a function of