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Measurements of the Functional Dynamics of Wild Type and K103N HIV-1 Reverse Transcriptase Reveal the Mechanism of Efavirenz Resistance

✍ Scribed by Schauer, Grant D.; Sluis-Cremer, Nicolas; Leuba, Sanford H.


Book ID
122118355
Publisher
Biophysical Society
Year
2013
Tongue
English
Weight
80 KB
Volume
104
Category
Article
ISSN
0006-3495

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## Abstract A three‐layered ONIOM model was used to study the interactions between efavirenz and the binding sites of HIV‐1 reverse transcriptase (RT): wild‐type and double mutant K103N/Y181C enzyme forms. Binding energies were determined and compared to describe the loss of activity of efavirenz w