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Measurement of the Relative Nucleophilicities of Thiolate Anions by the Base-Catalyzed Addition of Thiols to Maleic Anhydride1

โœ Scribed by Dmuchovsky, Basil; Zienty, Ferdinand B.; Vredenburgh, Walter A.


Book ID
111975521
Publisher
American Chemical Society
Year
1966
Tongue
English
Weight
594 KB
Volume
31
Category
Article
ISSN
0022-3263

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The asymmetric addition of trimethylsily
โœ Ian P Holmes; Henri B Kagan ๐Ÿ“‚ Article ๐Ÿ“… 2000 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 87 KB

Trimethylsilylcyanide has been added to a number of aldehydes using a highly active chiral catalyst. This procedure gives the TMS ethers of the corresponding cyanohydrins in excellent chemical yields with enantiomeric excesses of up to 59%. The reaction is believed to occur through hypervalent silic