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Measurement of Serum α1-Acid Glycoprotein and cei-Antitrypsin Desialylation in Liver Disease

✍ Scribed by Nathalie Serbource-Goguel; Michèle Corbic; Serge Erlinger; Geneviève Durand; Jean Agneray; Jeanne Feger

Publisher
John Wiley and Sons
Year
2007
Tongue
English
Weight
415 KB
Volume
3
Category
Article
ISSN
0270-9139

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✦ Synopsis

To determine whether the presence of circulating desialylated glycoproteins reflect the existence and/or the severity of liver disease, 73 patients were evaluated with liver biopsies, conventional liver function tests, and the measurement of the degree of desialylation of two glycoproteins al- acid glycoprotein (al-AGP) and al-antitrypsin (al-AT). A combination of two immunological methods, available as routine laboratory tests, was used for the determination of the desialylation of al-AGP and a,-AT. The severity of liver disease was assessed by a clinical classification depending upon the presence or absence of four complications (jaundice, ascites, hepatic encephalopathy, and weight loss). The presence of serum desialylated al-AGP did not allow detection of mild liver disease, but asialoa,-AGP (and to a lesser extent of asialo-al-(AT) correlated with the severity of liver disease. The sensitivity of desialylated a,-AGP in detection of severe liver disease was 65%, and its specificity was 80%.

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