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Measurement of paclitaxel in biological matrices: high-throughput liquid chromatographic–tandem mass spectrometric quantification of paclitaxel and metabolites in human and dog plasma

✍ Scribed by Michael S Alexander; Melissa M Kiser; Travis Culley; John R Kern; John W Dolan; James D McChesney; Jan Zygmunt; Steve J Bannister


Book ID
108497422
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
301 KB
Volume
785
Category
Article
ISSN
1873-376X

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✍ Anniek Schellen; Bert Ooms; Mark van Gils; Otto Halmingh; Erik van der Vlis; Dic 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 English ⚖ 49 KB 👁 1 views

The feasibility of high throughput on-line solid phase extraction/tandem mass spectrometry (SPE/MS/MS) is tested for target analysis of paclitaxel in human serum. The use of a dual Prospekt system, with parallel SPE and elution directly to the mass spectrometer, resulted in a cycle time of 80 second