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Measurement of O6-methylguanine-type adducts in DNA and O6-alkylguanine-DNA-alkyltransferase repair activity in normal and neoplastic human tissues

✍ Scribed by V.L. Souliotis; V. Zongza; V. Nikolopoulou; G.J. Dimitriadis


Book ID
113324114
Publisher
Elsevier Science
Year
1992
Tongue
English
Weight
581 KB
Volume
101
Category
Article
ISSN
1096-4959

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O 6 -Alkylguanine-DNA-alkyltransferase (ATase) is an important modulator of alkylating agent-induced toxicity and carcinogenicity, but those factors which influence the expression of this repair protein in human tissues are poorly characterised. In this study, we have determined ATase levels in macr