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Measurement of human blood brain barrier integrity using11C-inulin and positron emission tomography

✍ Scribed by Toshihiko Hara; Masaaki Iio; Takashi Tsukiyama; Fuji Yokoi

Publisher
Springer
Year
1988
Tongue
English
Weight
306 KB
Volume
14
Category
Article
ISSN
0340-6997

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✦ Synopsis

Positron emission tomography (PET) using 11C-inulin was demonstrated to be applicable to the clinical measurement of blood brain barrier permeability and cerebral interstitial fluid volume. Kinetic data were analyzed by application of a two compartment model, in which blood plasma and interstitial fluid spaces constitute the compartments. The blood activity contribution was subtracted from the PET count with the aid of the 11CO inhalation technique. The values we estimated in a human brain were in agreement with the reported values obtained for animal brains by the use of 14C-inulin.

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