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Measurement of glucose-6-phosphate dehydrogenase and glutathione reductase activity in patients with paracoccidioidomycosis treated with ketoconazole

✍ Scribed by Benedito Barraviera; Rinaldo Poncio Mendes; Paulo Câmara Marques Pereira; Jussara Marcondes Machado; Paulo Roberto Curi; Domingos Alves Meira

Publisher: Springer Netherlands
Year: 1988
Tongue: English
Weight: 364 KB
Volume: 104
Category: Article
ISSN: 0301-486X
DOI: 10.1007/bf00436932

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✦ Synopsis

Hemoglobin rates, hematocrit and glucose-6-phosphate dehydrogenase (G6PD) and glutathione reductase activities were measured in 38 patients with paracoccidioidomycosis treated with ketoconazole or sulfadoxin, and in 13 normal individuals. Ketoconazole-treated patients showed reduced G6PD and glutathione reductase activities. One of these patients was found to be G6PD-deficient and suffered a hemolytic episode during treatment, which, however, did not require interruption of therapy. The authors suggest that patients showing an erythrocyte enzyme defect should be monitored hematologically during treatment with ketoconazole. They also suggest that ketoconazole is an oxidant drug in addition to being a possible inhibitor of antioxidant erythrocyte enzymes.

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