Serum enzyme activities in patients with polycythemia and myelofibrosis. Glutamic oxaloacetic transaminase, glutamic pyruvic transaminase, lactic dehydrogenase, and glutathione reductase in serum of patients with polycythemia and myelofibrosis
✍ Scribed by Ruven Levitan; Louis R. Wasserman; Felix Wróblewski
- Publisher
- John Wiley and Sons
- Year
- 1960
- Tongue
- English
- Weight
- 215 KB
- Volume
- 13
- Category
- Article
- ISSN
- 0008-543X
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✦ Synopsis
ERUM LACTIC DEHYDROGENASE ACTIVITY (SLD)
S has been studied in some hematological diseases and was found to be elevated in the sera of patients with acute stem cell leukemia, chronic myelogenous leukemia,2.5 megaloblastic anemia, sickle cell anemia,', 8 and in acute hemolytic episodes.4
Four serum enzyme activities were determined in the serum of patients with polycythemia and myelofibrosis; the purpose of this presentation is to report on these observations. T h e enzymes studied were glutamic oxaloacetic transaminase (SCOT), glutamic pyruvic transaminase (SGPT), lactic dehydrogenase (SLD), and glutathione reductase (SGR).
Methods
Seven ty-seven patients observed at Memorial Center for Cancer and Allied Diseases, New York, N.Y., and the Mount Sinai Hospital New York, N.Y., were studied. T h e diagnostic conclusions were polycythemia Vera in 70 patients, secondary polycythemia in 2, and myelofibrosis in 5.
T h e methods of enzyme determinations were described previously: SGOT,~ S G P T , ~ S L D , ~ and SGR.' T h e normal values for these enzymes in the serum of healthy individuals as found in this laboratory are as follows: SCOT from 8 to 40 units per ml. (6.8 to 22.1); SGPT, 5 to 35 units per ml. (9. to 16.); SLD, 200 to 500 units per ml. (100. to 300.); and SGR, 10 to 70 units per ml. (15. to 40.). Venous blood samples were collected and handled as previously