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Measurement of DNA-protein crosslinks in mammalian cells without X-irradiation

✍ Scribed by Raymond Gantt; Edward V. Stephens; Sheila R. Davis

Book ID
102626865
Publisher
Elsevier Science
Year
1985
Tongue
English
Weight
345 KB
Volume
149
Category
Article
ISSN
0003-2697

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✍ Z. Galcheva-Gargova; G. N. Dessev πŸ“‚ Article πŸ“… 1987 πŸ› John Wiley and Sons 🌐 English βš– 319 KB

We have been able to demonstrate that a fraction of DNA becomes crosslinked to nuclear lamina shells isolated from Ehrlich ascites tumour cells irradiated with UV light. Terminal labeling of short DNA fragments covalently attached to proteins reveals that DNA has become crosslinked to all three lami