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Measurement of 8-hydroxy-2′-deoxyadenosine in DNA by liquid chromatography/mass spectrometry

✍ Scribed by Pawel Jaruga; Henry Rodriguez; Miral Dizdaroglu

Book ID: 114274802
Publisher: Elsevier Science
Year: 2001
Tongue: English
Weight: 339 KB
Volume: 31
Category: Article
ISSN: 0891-5849
DOI: 10.1016/s0891-5849(01)00594-9

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A method based on liquid chromatography (LC) combined with electrospray ionization tandem mass spectrometry for the analysis of the frequency of formation of 8-hydroxydeoxyguanosine (8OHdGuo), a biomarker of oxidative damage to DNA, has been developed. This analytical technique has the advantage ove