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Measurement error analysis for the determination of dopamine D2 receptor occupancy using the agonist radioligand [11C]MNPA

✍ Scribed by Shidahara, Miho; Ito, Hiroshi; Otsuka, Tatsui; Ikoma, Yoko; Arakawa, Ryosuke; Kodaka, Fumitoshi; Seki, Chie; Takano, Harumasa; Takahashi, Hidehiko; Turkheimer, Federico E

Book ID: 109871230
Publisher: Nature Publishing Group
Year: 2009
Tongue: English
Weight: 618 KB
Volume: 30
Category: Article
ISSN: 0271-678X
DOI: 10.1038/jcbfm.2009.193

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## Abstract (__R__)‐(−)‐2‐[^11^C]Methoxy‐__N__‐__n__‐propylnorapomorphine ([^11^C]MNPA ([^11^C]2)) is an agonist radioligand of interest for imaging D~2~/D~3~ receptors __in vivo__. Here we sought to develop an improved radiosynthesis of this radioligand. Reference 2 was synthesized in nine steps w