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Mean Residence Times of Multicompartmental Drugs Undergoing Reversible Metabolism

โœ Scribed by Haiyung Cheng; William J. Jusko

Book ID
110341244
Publisher
Springer US
Year
1990
Tongue
English
Weight
737 KB
Volume
07
Category
Article
ISSN
0724-8741

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๐Ÿ“œ SIMILAR VOLUMES

A method for calculating the mean absorp
A method for calculating the mean absorption time of drugs undergoing reversible and first-pass metabolism
โœ Haiyung Cheng; Linyee Shum ๐Ÿ“‚ Article ๐Ÿ“… 1993 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 412 KB ๐Ÿ‘ 2 views

A method has been derived for calculating the mean absorption time of an oral drug and its interconversion metabolite which is generated from the drug systemically and presystemically. The method evolves from the convolution integral and requires plasma AUC and AUMC values after separate intravenous

Mean residence time of drugs administere
Mean residence time of drugs administered non-instantaneously and undergoing linear tissue distribution and reversible metabolism and linear or non-linear elimination from the central compartment
โœ Haiyung Cheng ๐Ÿ“‚ Article ๐Ÿ“… 1995 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 409 KB ๐Ÿ‘ 2 views

Based on disposition decomposition analysis (DDA), equations for the mean residence times (MRT) in the body are derived for a drug and its interconversion metabolite that undergo linear tissue distribution and linear or non-linear elimination from the central compartment after non-instantaneous admi