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MDR1 polymorphisms (G2677T and C3435T) in B-chronic lymphocytic leukemia

✍ Scribed by Saher K. Elden Hussien, Asmaa Ahmed Abdel-Aal…

Book ID
120915482
Publisher
Springer-Verlag
Year
2012
Tongue
English
Weight
278 KB
Volume
23
Category
Article
ISSN
1618-5641

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C1236T, G2677T/A, and C3435T polymorphism of the multidrug resistance (MDR1) gene have substantial impact on expression or activity of P-glycoprotein (Pgp). We developed new methods based on amplification refractory mutation system (ARMS) to detect these polymorphisms. Tetra-primers amplification in