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Frequency of the C1236T, G2677T/A and C3435T MDR1 gene polymorphisms in the Serbian population

✍ Scribed by Milojkovic, Maja; Stojnev, Slavica; Jovanovic, Ivan; Ljubisavljevic, Srdjan; Stefanovic, Vladisav; Sunder-Plassman, Raute

Book ID
122180350
Publisher
Elsevier
Year
2011
Tongue
English
Weight
145 KB
Volume
63
Category
Article
ISSN
1734-1140

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Detection of C1236T, G2677T/A, and C3435
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C1236T, G2677T/A, and C3435T polymorphism of the multidrug resistance (MDR1) gene have substantial impact on expression or activity of P-glycoprotein (Pgp). We developed new methods based on amplification refractory mutation system (ARMS) to detect these polymorphisms. Tetra-primers amplification in