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Mdm2 inhibition of p53 induces E2F1 transactivation via p21

✍ Scribed by Wunderlich, Mark; Berberich, Steven J


Book ID
110066726
Publisher
Nature Publishing Group
Year
2002
Tongue
English
Weight
241 KB
Volume
21
Category
Article
ISSN
0950-9232

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## Abstract We report that MDM2, a negative regulator of p53, can bind to EBNA‐5. Using GST pull‐down assay, immunoprecipitation, surface plasmon resonance and immunostaining of lymphoblastoid cells, we found that trimolecular complexes are formed between EBNA‐5, MDM2 and p53, where MDM2 serves as