MDM2 gene amplification in a pediatric malignant fibrous histiocytoma (MFH)
โ Scribed by J.L. Wilson; S. Masui; J.F. Lim; D. Kalousek; D. Horsman; P.H.B. Sorensen
- Book ID
- 107740665
- Publisher
- Elsevier Science
- Year
- 1995
- Tongue
- English
- Weight
- 157 KB
- Volume
- 28
- Category
- Article
- ISSN
- 0009-9120
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Changes in chromatin structure as determined from DNAse I hypersensitive site analysis are associated with c-myc amplification and increased transcript/protein levels in malignant fibrous histiocytoma (MFH) cell lines. A DNAse I hypersensitive site near the PO promoter region was observed in one MFH
## Abstract ## BACKGROUND Malignant fibrous histiocytoma (MFH) is a controversial entity. In the current study, the authors reviewed their institutional experience with these tumors to characterize their clinical features in pediatric patients and assess the impact of surgical resection on outcome