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MDM2 antagonists activate p53 and synergize with genotoxic drugs in B-cell chronic lymphocytic leukemia cells

✍ Scribed by Coll-Mulet, L.


Book ID
121754115
Publisher
American Society of Hematology
Year
2006
Tongue
English
Weight
293 KB
Volume
107
Category
Article
ISSN
0006-4971

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## Abstract Signal transduction and apoptosis in B‐cell chronic lymphocytic leukemia (CLL) cells with a post‐germinal center (GC) phenotype were studied. Specific activation of the cells was induced by a combination of soluble anti‐CD40 monoclonal antibody and interleukin‐4 (CD40/IL‐4) and nonspeci