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MCSGP: A new dimension in purification


Publisher
John Wiley and Sons
Year
2007
Tongue
English
Weight
60 KB
Volume
98
Category
Article
ISSN
0006-3592

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πŸ“œ SIMILAR VOLUMES


A continuous multicolumn countercurrent
✍ Lars Aumann; Massimo Morbidelli πŸ“‚ Article πŸ“… 2007 πŸ› John Wiley and Sons 🌐 English βš– 554 KB

## Abstract Biomolecules are often purified via solvent gradient batch chromatography. Typically suitable smooth linear solvent gradients are applied to obtain the separation between the desired component and hundreds of impurities. The desired product is usually intermediate between weakly and str

A semicontinuous 3-column countercurrent
✍ Lars Aumann; Massimo Morbidelli πŸ“‚ Article πŸ“… 2007 πŸ› John Wiley and Sons 🌐 English βš– 223 KB

## Abstract The recently developed continuous Multicolumn Countercurrent Solvent Gradient Purification (MCSGP) Process has been reduced to a fully equivalent semicontinuous setup with only three chromatographic columns and three gradient pump modules. Actually the 3‐column MCSGP unit can even achie

Parametric study of a 6-column countercu
✍ Lars Aumann; Guido Stroehlein; Massimo Morbidelli πŸ“‚ Article πŸ“… 2007 πŸ› John Wiley and Sons 🌐 English βš– 659 KB

## Abstract The novel β€œmulticolumn countercurrent solvent gradient purification” (MCSGP) process has been modeled for the purification of a polypeptide mixture characterized by a strong non‐linear competitive adsorption isotherm. As a model system, the purification of an industrial polypeptide mixt

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