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MCPH1/BRIT1 cooperates with E2F1 in the activation of checkpoint, DNA repair and apoptosis

✍ Scribed by Yang, Shan-Zhong; Lin, Fang-Tsyr; Lin, Weei-Chin


Book ID
109850058
Publisher
Nature Publishing Group
Year
2008
Tongue
English
Weight
950 KB
Volume
9
Category
Article
ISSN
1469-221X

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## Abstract Apaf‐1 and the cysteine proteases known as caspases are genes central to the intrinsic apoptotic pathway in the retina. Previously, we have shown that histone deacetylase (HDAC) activity regulates Apaf‐1 expression in the retina. In this study, we unravel the detailed molecular mechanis