MCM7 amplification and overexpression are associated with prostate cancer progression
β Scribed by Ren, B; Yu, G; Tseng, G C; Cieply, K; Gavel, T; Nelson, J; Michalopoulos, G; Yu, Y P; Luo, J-H
- Book ID
- 110070167
- Publisher
- Nature Publishing Group
- Year
- 2005
- Tongue
- English
- Weight
- 269 KB
- Volume
- 25
- Category
- Article
- ISSN
- 0950-9232
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We analyzed normal/tumor DNA pairs obtained from 46 patients with prostate cancers (stage B, 16 cases; C, 10 cases; D1, 4 cases; and endocrine therapy-resistant cancer-death, 16 cases) for loss of heterozygosity using 32 microsatellite markers on chromosome 18. Seventeen of the 46 cases (37%) showed
## Abstract Novel molecular markers that are associated with prostate cancer (PCa) progression will provide valuable information in the diagnosis and treatment of the disease. Extracellular matrix metalloproteinase inducer (CD147) has been demonstrated to be involved in tumor invasion, metastasis,