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MC1R Genotype Modifies Risk of Melanoma in Families Segregating CDKN2A Mutations

✍ Scribed by Neil F. Box; David L. Duffy; Wei Chen; Mitchell Stark; Nicholas G. Martin; Richard A. Sturm; Nicholas K. Hayward

Book ID
117853696
Publisher
American Society of Human Genetics
Year
2001
Tongue
English
Weight
434 KB
Volume
69
Category
Article
ISSN
0002-9297

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## Abstract __CDKN2A__ is a major susceptibility gene for cutaneous malignant melanoma (CMM), but the variable penetrance and clinical manifestations among mutation carriers suggest the existence of modifier factors. The goal of this study was to identify modifier genes for CMM in CMM‐prone familie