Maturity onset diabetes of the young (MODY) is a genetically heterogeneous form of type 2 diabetes that is characterized by autosomal dominant inheritance, onset in early adulthood and a primary defect in insulin secretion. Mutations in at least six genes have been shown to underlie MODY, including
Maturity-onset diabetes of the young (MODY): how many cases are we missing?
β Scribed by B. M. Shields; S. Hicks; M. H. Shepherd; K. Colclough; A. T. Hattersley; S. Ellard
- Publisher
- Springer
- Year
- 2010
- Tongue
- English
- Weight
- 242 KB
- Volume
- 53
- Category
- Article
- ISSN
- 0012-186X
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## Maturity -onset diabetes of the young (MODY) resulting from mutations in the glucokinase (GCK) gene accounts for approximately 20% of MODY in the UK. W e have performed fluorescent single stranded conformation polymorphism (F-SSCP) analysis or direct sequencing of the GCK gene in 212 patients re
The association between DNA insertion sequences located near the insulin gene and the dominantly inherited maturity-onset diabetes of young people was studied in a large family. The distribution of the restriction fragments was compatible with Mendelian segregation. However, no linkage was found bet